Arpan Parekh

Mentor: Dr. Daiqing Liao
College of Medicine
 
"I wanted to further my understanding of basic and advanced lab techniques in labs and the basic sciences. The department of anatomy and cell biology presented me with a unique opportunity to do just that, while learning about and advancing new anti-cancer therapies with a basis in epigenetics and cell biology."

Major

Economics

Minor

N/A

Research Interests

  • Anti-cancer therapeutic uses of KATs and HDACs
  • Health care policy

Academic Awards

  • Florida Incentive Scholarship
  • JAINA Academic Scholar
  • National Merit Finalist

Organizations

  • Gator Premedical Guide
  • UF Climbing Team
  • Outdoor Adventure Recreation

Volunteer

  • Westside Samaritans Clinic
  • Shands ER

Hobbies and Interests

  • Hiking
  • Rock Climbing
  • Hip-hop
  • Writing

Research Description

An examination of novel HDAC inhibitors as anti-cancer therapeutics
Protein lysine acetyltransferases (KATs) catalyze the acetyl attachment to lysine side chains of protein substrates that include histones and many other cellular proteins. Deacetylases (HDACs) catalyze the reverse reaction to remove the attached acetyl group. Acetylation of protein substrates impacts their stability and functions in a variety of cellular pathways such as gene transcription, intracellular trafficking and metabolisms. Both KATs and HDACs are implicated in human diseases and represent rational therapeutic targets. My research focuses on testing various novel HDAC inhibitors on cellular effects and mechanisms of action using current molecular cell biology techniques.