Bankole Olowofela


Bankole Olowofela
Mentor: Dr. Julio Duarte
College of Pharmacy
 
"Research is an aspect of learning that forces individuals to think in a way different from that of regular classes. In addition to that, discoveries within research allow for drastic changes and improvements in areas such as medicine. For those reasons, I decided to get involved within the research community and gain some experience within the field."

Major

Biology

Minor

N/A

Research Interests

  • Pharmacogenomics
  • Concussions

Academic Awards

  • Florida Incentive Scholarship 2015
  • National Achievement Scholarship 2015
  • Dean’s List 2015
  •  University Scholars Program 2016

Organizations

  • Campus Crusade
  • Multicultural Association of Pre-Health Students
  • Circle K

Volunteer

  • Greenhouse Church
  • UF Health Shands Hospital
  • Project Connect

Hobbies and Interests

  • Football
  • Speed training

Research Description

Beyond CYP2C19: Additional Genomic Predictors of Clopidogrel Response in Patients
Clopidogrel is an antiplatelet drug used alone or with aspirin to treat patients who have suffered heart attacks, received coronary stents, or have acute coronary syndrome in addition to other heart related diseases. Up to 25% of the patients put on the medication receive limited or no benefit; and when speaking of millions of people being prescribed, that takes shape into a massive number of unaided patients and pointless prescriptions. Research has shown that patients with variability in the gene encoding the Cytochrome P-450 2C19 enzyme (CYP2C19) is associated with clopidogrel response. We will test 3 other genes outside of CYP2C19 (ABCB1, PON1, and PEAR1) in order to find out if their expression has any effect on patient response to clopidogrel. If any or all of these genes show a positive link, then we will be able to know more about how patients react to this drug. This will give doctors the ability to more precisely prescribe clopidogrel, and potentially others drugs in the future to come. Depending on results as well as time, this project could also expand to investigate the effects of the other genes on clopidogrel response.