Bradley Maller

Mentor: Dr. Grant McFadden
College of Medicine
 
"Having always wanted to pursue a career in medicine, I wanted to get involved with research in order to better decide if research is something I would want to continue throughout my medical career."

Major

Biochemistry

Minor

N/A

Research Interests

  • Immunology
  • Virology
  • Oncology

Academic Awards

  • Anderson Scholar Award 2014
  • Dr. Frank Maturo Outstanding Greek Scholar 2014
  • IFC Scholar of the Month October 2014
  • IFC Man of the Month March 2014
  • University Scholars Program 2015-2016

Organizations

  • American Medical Student Association (AMSA)
  • Student Honors Organization
  • Sigma Nu

Volunteer

  • Boys and Girls Club
  • North Florida Regional Medical Center
  • Shands Hospital

Hobbies and Interests

  • Football
  • Reading
  • The Walking Dead

Research Description

The Role of M013 Against Type 1 Interferon Response Pathways
M013, a multifunctional, immunosubversive protein produced by Myxoma Virus, is important for virus virulence by co-regulating both inflammasome regulated pro-inflammatory cytokine secretion and activation of the NF-kB signaling pathway. Additionally, M013 is known to aid Myxoma Virus in circumventing the type 1 interferon response. The goal of my research project is to identify the binding partners of M013 in the type 1 interferon response signaling pathways. I will be using a variety of tests to determine M013 protein’s binding partners. Western blotting will be crucial for identifying the specific proteins found in my samples and Co-Immunoprecipitation will be used to identify protein-protein interactions. Additionally, Enzyme-Linked Immunosorbent Assays (ELISAs) will allow me to measure the concentrations of the proinflammatory cytokines and chemokines.