Larry Nguyen

Mentor: Dr. Xin Qi
College of Pharmacy
 
"I got involved with research because I want to actively engage in the scientific process, push the boundaries between science and medicine, and innovate the field with new discoveries. Dr. Qi's lab provided me the foundation and establishment to develop and enhance my skills and knowledge in scientific research. With the opportunities provided by the University Scholars Program, I am able to pursue my passion for research and serving my community."

Major

Chemistry

Minor

Mathematics

Research Interests

  • Cancer Biology
  • RNA-Protein Interactions
  • Genotyping

Academic Awards

  • Machen Florida Opportunity Scholar
  • University Scholars Program
  • Graham Civic Scholar
  • Sunburst Foundation Scholarship

Organizations

  • Bob Graham Center for Public Service
  • UF Model United Nations
  • Multicultural Association of Pre-Health Students

Volunteer

  • UF Health Shands Hospital
  • American Red Cross
  • YMCA

Hobbies and Interests

  • Cycling
  • Fishing
  • Nonprofit Organization
  • Kayaking

Research Description

Discovery of Aminoacyl-tRNA Synthetase Inhibitors as Anti-Cancer Agents
Aminoacyl-tRNA synthetase (aaRS) are enzymes that play a significant role in protein synthesis due to their critical role in the process of translation. Inhibiting the activity of aaRS would decrease the cells’ ability to produce proteins, thus destroying the protein supply for cell growth and causing cell apoptosis or other cell death. Recently, research effort on aaRS inhibitors has focused on the development of compounds mimicking aminoacyl adenylates to deplete the charging endogenous tRNAs. Among such compounds, sulfamides stand out because of their potency to inhibit cancer cell growth. Since aaRSs could be directly link to tumorigenesis as a result of their non-canonical functions in angiogenesis, immune responses and signal transduction pathway, aaRS inhibitors is an ideal model system for developing novel anticancer agents leading to a potential application in regulating oncoprotein expression and modification for anti-cancer therapeutics.