Meaghan Holzworth

Mentor: Dr. Michelle Gumz
College of Medicine
 
"I initially got involved with research because I wanted to see everything that I was learning put into action. Actually conducting the experiments has been invaluable in that I have gained a greater understanding for how everything truly works rather than just relying on memorization from lectures."

Major

Health Science

Minor

Spanish

Research Interests

  • Circadian Biology
  • Renal Physiology
  • Hypertension

Academic Awards

  • Sunshine State Scholarship Recipient 2013-2017
  • President's Honor Roll 2013-2016
  • University Scholars Program 2016

Organizations

  • PreProfessional Service Organization
  • PreHealth Diplomats

Volunteer

  • Shands NICU
  • Noah's Endeavor
  • Alachua County Humane Society

Hobbies and Interests

  • Running
  • Soccer
  • Travel

Research Description

Renal Regulation of ET-1 Expression
Endothelin-1 (ET-1) is a peptide hormone in the body that mediates the complex regulation of blood pressure (BP). Although ET-1 has been highly researched, its regulation is still not clear. This project will be examining different ways that ET-1 is regulated in the kidney with implications for controlling ET-1 expression and activity in relation to hypertension, an outcome of poorly regulated BP. EDN1-AS is a novel long, non-coding RNA whose regulatory mechanisms are unknown but will be explored through mutating sites on its promoter. The project will also look into regulatory mechanisms involving the Mineralocorticoid Receptor and Per1, an important Clock protein that helps maintain physiological circadian rhythms.