Min Chae

Mentor: Dr. Paul Oh
College of Medicine
 
"I always believed that it's one thing to learn things from textbooks, and anther thing to be able to apply the learned material in real-life settings. In my perspective, the latter is what makes one valuable individual in the workforce. It seemed to me that being part of a research team would not only challenge me to improve the aforementioned ability, but also improve my ability to think on my feet when a problem occurs. ."

Major

Biology

Minor

N/A

Research Interests

  • Medicine
  • Music and Medicine
  • Language

Academic Awards

  • University Scholars Program 2016
  • Bright Futures 2015-2017

Organizations

  • HEAL

Volunteer

N/A

Hobbies and Interests

  • Vocal Performance
  • Reading

Research Description

Histological Analysis of AVMs in the Nose and Jaw
Hereditary Hemorrhagic Telangiectasia (HHT) is a autosomal dominant vascular disorder that is characterized by mucocutaneous telangiectases (dilation of capillaries in the transition region between the mucosa and the skin), which often cause epistaxis (spontaneous and recurrent nosebleeds), and arteriovenous malformations (AVMs), the latter being the direct connection between arteries and veins without the intervention of capillaries. It has been shown that formation of AVMs requires both the mutation of the ALK-1 (activin receptor-like kinase 1) or ENG (endoglin) as well as wounds on the skin of the affected individual. In the project that I am a part of, I will be studying the AVMs in the mice that have been genetically modified to mimic the required genotype and compare the resulting phenotype with that of mice that have not been genetically modified. This will allow us to make connections between the occurrence of AVMs in the nasal canal which causes the characteristic epistaxis and the exact genotype that causes the disorder.