Thuy Nguyen

Mentor: Dr. Edward Chan
College of Dentistry
 
"I was enrolled in the Science for Life course during my first semester at University of Florida. Dr. Chan was the first professor to present his research during this seminar-styled course and his discussion sparked my interest and ignited my scientific curiosity. With the desire to further pursue my curiosity, I contacted Dr. Chan and was able to discuss with him my interest in gaining research experience. In the following summer, I started working on Rods and Rings under my research mentor S. John Calise."

Major

Applied Physiology and Kinesiology

Minor

N/A

Research Interests

  • Rods and Rings

Academic Awards

  • Wentworth Honors Scholarship - 2014
  • Dean's List - Multiple Semesters
  • University Scholars Program 2015-2016

Organizations

  • Volunteers Around the World
  • Honors Ambassadors
  • Study Abroad Peer Advisors

Volunteer

  • Mobile Outreach Clinic
  • Project Downtown
  • Global Medical Training

Hobbies and Interests

  • Running
  • Reading
  • Hiking
  • Photography

Research Description

Exploring Potential Novel Components of Rod and Ring Structures in Human Oral Cells
In attempt to further understand the expression of rod and ring structures (RR) and their role in oral cancer cells, I will investigate the properties of potential new RR components. My study will examine the properties and kinetics of RR in relation to these new components and help to further characterize the anatomy and physiology of these protein aggregates that are not yet fully understood. The initial part of this project will involve studies comparative to past investigations of IMPDH2 and CTPS1, two known protein components of RR. For example, I will analyze the effects of inhibitors of the GTP and CTP synthetic pathways as well as alterations of nutrient levels in regard to the potential components, specifically looking at the morphology, assembly, and disassembly of RR. This, along with siRNA knockdown experiments, will elucidate the relationship between IMPDH2, CTPS1, and hypothetical proteins within the structure. Once additional components are identified, later experiments will involve examination of proteins known to be associated with these newly identified components. Preliminary results have been obtained in the human cervical cancer cell line HeLa, and it is within my intentions to extend this study to the oral cavity as well as other species.