Mentor: Dr. J. Hobbs
College of Medicine
"I wanted to gain research experience that not only reflected my work thus far, but also to utilize new skill sets. For this academic year, I would like to be published a couple times and also keep up with juggling work/courses/volunteering/research."
- Effect of molecular part of the brain on human psyche
- Bob Graham Civic Scholar, Summer and Fall 2011
- National Collegiate Scholar, Spring 2010
- IMPACT Autism
- Phi Eta Sigma
- Sidney Lanier School for Devleopmental Disabilities
- IMPACT Autism
Hobbies and Interests
- Listening and playing music
- Reading psychology, non-fiction books
In Vitro Cytokine Induction in B19-Infected Thyroid Cancer Cell Lines
The pathogenic parvovirus B19 (B19) is a known cause of several human diseases ranging from mild to severe in nature. Recently, our laboratory and others have shown that B19 is highly associated with certain types of thyroid cancer including anaplastic thyroid carcinoma, one of the most aggressive and deadly forms of human cancer. B19 is known to regulate the production of some inflammatory cytokines such as TNF- and IL-6 using in vitro cell culture. Cytokines are membrane bound proteins that regulate inflammatory cell growth, activation and differentiation (Dranoff 2004). The link between inflammation and cancer is of increasing interest and concern in determining the etiology, pathogenesis, and therapeutics of cancer. Although studies have detected B19 in thyroid tissues, no study has determined which cytokines are specifically upregulated by B19 in thyroid cancer, particularly in vivo. We have done so previously in thyroid cell lines transfected with the B19 NS1 gene. The B19 NS1 gene is considered an activator of inflammatory cytokine expression in a newly infected B19 cell line (Fu 2002). Results suggest that B19 may induce granulocyte colony stimulating factor (GCSF), a cytokine that plays a key role in recruitment of epithelial progenitor cells to tumors. The goal of this project is to assess production of various cytokines, specifically TNF-alpha, IL-1alpha, GCSF, IL-6, and IP10, in supernatants from thyroid cancer cells transfected with the B19 protein NS1. We hypothesize that NS1 regulates the production of inflammatory cytokines in thyroid cancer, particularly GCSF.