Statins are a class of cholesterol lowering drugs that inhibit an enzyme called HMG-CoA reductase in the mevalonate pathway, a key factor in cholesterol production in the liver. Statin therapy is currently used to significantly reduce the occurrence of cardiovascular events. Clinical studies have shown that patients that undergo statin therapy are at greater risk of developing insulin resistance and becoming diabetic with a mechanism that is not fully understood. Consequently, some patients also have to be treated for diabetes in addition to receiving statin treatment. The significance of this study is to understand diabetogenesis of the statin class of drugs. Diabetes is associated with many complications including but not limited to renal failure, retinopathy (blindness) and cardiovascular associated diseases. In this study, the focus will be on preadipocyte SGBS (Simpson-Golabi-Behmel Syndrome) cells as well as visceral and subcutaneous adipose tissue (VAT & SAT) of obese Shands patients who have undergone bariatric surgery. Cells will be cultured in 6-well plates until they are confluent and are fully differentiated adipocytes. They will then be treated for 6-10 days with the chosen statins for this experiment (Atorvastatin & Simvastatin). The concentrations for this experiment were selected based upon current literature in order to mimic conditions experienced by cells in vivo. After statin treatment, cells were either stained with Oil Red O dye in order to measure adipocyte maturation, or harvested to be used later. Harvested cells are then lysed in order to extract RNA and with that RNA, cDNA is made which is ultimately used to perform Real Time PCR for gene analysis. When conducting gene analysis experiments, the major genes of concern are Adiponectin, Glut4 (glucose transporter type 4), PPAR-ɣ1 (Peroxisome proliferator-activated receptor gamma), PPAR-ɣ2 and Insulin Receptor. Hopefully this analysis will provide more insight on this mechanism.