"I applied to the University Scholars Program in order to further commit myself to the research lab that I am presently a member of. I hope to discover what scientific research is all about and to determine whether or not research is a path that I want to pursue in the future. My goals for the year are to develop a keen understanding for my research topic and to collect enough significant data to produce a publication."
Applied Physiology and Kinesiology
Currently, my primary academic interest lies in science and medicine. My research interest lies in the biological and cellular fields.
Academic and Other Awards
- University Scholars Program Scholarship (2011-2012)
- Danny Eggart Endowed Memorial Scholarship (2011)
- Youth Foundation Hadden Scholarship (2009-Present)
- UF Department of Recreational Sports
- UF Intramural Football
- UF Intramural Softball
- UF Intramural Volleyball
I volunteer through the Department of RecSports contributing to various projects around the community.
Hobbies and Interests
- Cooking with friends and family, listening to music, playing piano, guitar and drums.
The Effect of Resveratrol Treatment and Caloric Restriction on Doxorubicin-Induced Toxicity in Rat Skeletal Muscle
In rodents, caloric restriction (CR) has been shown to increase health and longevity by altering mitochondrial-associated bioenergetic pathways. Resveratrol (RSV) is a polyphenol found in red wine shown to have similar effects as CR when administered to rodents. RSV and CR both activate the sirtuin protein family which regulate mitochondrial function and reduce mitochondrial-mediated oxidative stress. Doxorubicin (DOX) is an effective chemotherapeutic agent but has limited clinical use due to its off-target tissue toxicity. DOX-induced muscle toxicity results from increased free radical production contributing to impaired mitochondrial regulatory processes such as apoptosis and autophagy. Although RSV and CR have been shown to improve mitochondrial function in skeletal muscle, the cellular and molecular mechanisms remain largely unknown. The purpose of the current study is to determine whether RSV (50 mg/kg/day) and CR (20% reduced AL) can attenuate DOX-induced toxicity in skeletal muscle. We propose that RSV and CR (6weeks) will improve mitochondrial function and reduce oxidative stress following DOX treatment. Aged F344xBN rats (26 months) were divided into eight groups (n=4): ad libitum (AL), CR, RSV, RSV+CR; and injected with either DOX (20 mg/kg IP; 7days) or saline. A variety of experimental techniques will be employed to achieve the purposes, including Western Blot Analyses (examination of proteins by gel electrophoresis), and Mitochondrial Enzyme Activities (assesses overall mitochondrial content and function in various tissues). We anticipate both CR and RSV treatment will independently improve mitochondrial function, reduce mitochondrial-mediated apoptotic susceptibility, and potentially alter autophagic mechanisms associated with DOX treatment. The findings from these studies will possibly unravel some underlying mechanisms involved in the mitochondrial-associated dysfunction that occurs with aging and as the result of acute oxidative stress. The research outlined in this project is aimed to determine the beneficial CR- and RSV-induced molecular and biochemical adaptations in skeletal muscle of aged animals.