Bhupaul Ramsuchit

Bhupaul Ramsuchit
Mentor: Dr. Michael Moorhouse
College of Public Health and Health Professions
 
"As a pre-medical undergraduate student interested in becoming a physician, I enjoy learning about medicine and the research that influences medical practice and clinical methods. Working in Dr. Clayton Mathews' Type 1 Diabetes lab helps me to understand the bridge that connects these two, while exposing me to a large range of disease mechanisms and pathology. In addition, it facilitates the development of critical thinking skills and lab techniques giving me a seat at the forefront of scientific discovery and evidence based medicine."

Major

Health Science

Minor

Chemistry; Anthropology

Research Interests

  • Type 1 Diabetes
  • Sleep Disorders
  • Immunology

Academic Awards

  • University Scholars Program
  • PHHP Honors Program
  • Emergency Medical Responder Certification
  • BLS Certification

Organizations

  • Gator EMS
  • Microbiology Teaching Assistant

Volunteer

  • UF Health
  • Gator EMS
  • WellCare Medication Therapy Management Call Center

Hobbies and Interests

  • Sports
  • Traveling
  • Cooking

Research Description

Identification of the Molecular Mechanism of Idd22 Based Protection against Type 1 Diabetes

Over the years, the prevalence of Type 1 Diabetes (T1D) has soared worldwide. This devastatingly difficult disease has no cure and is managed only through life-saving, intensive insulin therapy. There is a clear need for new and innovative therapeutics that will only be developed by novel lines of investigation. The Alloxan Resistant (ALR) mouse strain provides such an opportunity, as this animal model strongly resists the development of autoimmune T1D. The resistance is heritable and dominant, however the specific gene(s) that modulate such resistance have not yet been identified. Therefore, my research goal with the Mathews’ lab is to identify the genes that defend against diabetes within the highly-T1D protective Insulin Dependent Diabetes 22 locus. This will be accomplished using several specialized mouse models called recombinant congenic strains (RCS). By using a panel of RCS, we can map the protective region on chromosome 8 and, subsequently, isolate the gene(s) that confer such resistance. In addition, by comparing gene expression levels the ALR mouse to both protected and susceptible RCS, we can also generate evidence as to how Idd22 provides protection. Identification of the gene(s) responsible for protection and the mechanism of action of Idd22 will provide new clues towards finding new therapeutic targets in the fight against Type 1 Diabetes.