Harris Krause

Mentor: Dr. Yiider Tseng
College of Engineering
 
"I got involved in research to gain more hands on experience in my area of interest and to see if academia/research would be a good career fit for me."

Major

Chemical Engineering

Minor

Biomolecular

Research Interests

  • Extra Cellular Matrix
  • Cell Migration
  • Molecular and Cellular Biology

Academic Awards

  • University Scholars Program
  • American Debate Association 2011-2012 Novice National Champion

Organizations

  • UF Speech and Debate Society

Volunteer

  • Food for Kids

Hobbies and Interests

  • Running
  • Scuba Diving

Research Description

Quantitative characterization of the effects of the Extra Cellular Matrix (ECM) on the Migration of Glioblastoma Multiforme Cells.

Glioblastoma multiforme is an extremely aggressive form of brain cancer whose derives its lethality from the speed at which the cancer metastasizes. There are many studies that demonstrate that varying the rigidity of the ECM and the type of proteins that make up the ECM each individually affects the Glioblastoma’s migratory capacity but no study has been done to show how these individual parameters which share similar molecular pathways might affect each other. This study aims to better quantify how cellular migration is affected by different combination of ECM proteins and rigidity, and how the roles of RhoGTPases interplay with those activities.