Mentor: Dr. Yiider Tseng
College of Engienering
"I applied to the scholars program so that I may establish great research habits and become accustomed to the research process. The rigor of the program also helps ensure I remain dedicated to the project in a structured and timely manner. This coming year, I hope to see my project come to fruition."
- Mechanics of Brain Function
- Arresting the Progression of Neurodegenerative Diseases
- Development of Prosthetics
Study Abroad Scholarship (2010)
University Scholars Program Stipend (2012-2013)
Anderson Scholar, various Honor Roles
Hobbies and Interests
Tae Kwon Do
Research DescriptionThe importance of Hedgehog-Tiam1-Rac1 signalling in glioblastoma
The purpose of this experiment is to elucidate the signaling pathway involving classical hedgehog (Hh), T-cell lymphoma and metastasis I (Tiam1), and Rac1 in malignant glioblastoma multiforme (GBM), and help explain migration characteristics of GBM in relation to the altered hedgehog pathway. The hedgehog pathway plays a very important role in neuronal and glial differentiation, while Rac1, a small RhoGTP-ase, plays an important role in cell motility and lamellipodia formation. The two cellular mechanisms are possibly linked in glial cells by Tiam1, a guanine exchange factor used in activating Rac1. We can determine the extent of relation by selectively choosing shRNA molecules to knockdown particular pathway components. Through microscopy and MATLAB analysis, we can determine the degree of association pathway components are to each other and the linearity of the pathway. GBM is known to exhibit high levels of hedgehog and Rac1 activity. The high Rac1 activity is particularly troublesome, as it can assist a cancerous cell to invade healthy tissues. Knowledge of which pathways contribute to this metastatic phenotype could be used in the development of more effective therapies, especially in a cancer so deadly.