Mentor: Dr. Peter J. Adhihetty
College of Health and Human Performance
"I applied to the University Scholars Program in order to explore my interest in scientific research. I hope to become a more active member of my lab, and gain a better understanding of laboratory techniques and procedures. For the academic year, my goals are to be successful in both the classroom and lab, while continuing with my extracurricular activities."
- Applied Physiology and Kinesiology
- Mitochondrial Regulation
- Florida Bright Future, 2011
- Scholar Athlete of Seminole Ridge High School, 2011
- University Scholars Program Scholarship, 2011-2012
Hobbies and Interests
- Playing flag football
- Listening to music
- Spending time with friends and family
Effect of Exercise on Mitochondrial Regulation in Prostate Tumors and Skeletal Muscle of Rats
Tumors are associated with dysregulated mitochondrial-mediated apoptosis and impaired mitochondrial metabolism. While exercise has been shown to reduce mitochondrial-mediated apoptosis and improve mitochondrial bioenergetics in various tissues, its effect on tumor growth in the prostate is unknown. Additionally, the effect exercise on tumor growth/progression and the release of inflammatory cytokines, and its effects in peripheral skeletal muscle are relatively unknown. The purpose of the study is to evaluate whether mitochondrial apoptotic markers and mitochondrial content will differ in tumors and skeletal muscle from, 1) non-tumorigenic control (NT; n=7 group), 2) non-tumorigenic exercise trained (NTE; 10 weeks treadmill training), 3) tumor-bearing control (TB), 4) tumor-bearing exercise-trained (TB-E). A variety of experimental techniques will be employed to achieve the purposes, and Dr. Adhihetty has informed me that I will be learning the following techniques: 1) Western Blot Analyses (examination of proteins by gel electrophoresis), 2) Mitochondrial Enzyme Activities (assesses overall mitochondrial content and function in various tissues). The findings from these studies will potentially unravel some of the underlying mechanisms involved in the mitochondrial-associated dysfunction that occurs with tumor progression/proliferation and its effect on peripheral skeletal muscle. Additionally, the results of this study will determine whether exercise is beneficial or deleterious towards the tumor microenvironment and peripheral muscle. Furthermore, the results of the current study may have far-reaching clinical implications with respect to determining whether to incorporate an exercise program to prostate cancer patients as part of their therapeutic intervention.