Mentor: Dr. Colin Sumners
College of Medicine
"I saw the Scholars program as an opportunity to exercise alternative outlets that may have otherwise been overlooked at the University of Florida. These include the opportunity to collaborate with other PI's here at the University in an attempt to increase the number of Stage I and II pilot studies that are conducted. After having conducted four extensive years of research on Ischemic Stroke I plan on presenting to as many conferences as possible during my last year at the University in an attempt to gain further insight into my specific interests from other scientists/researchers around the world and to further extend clinical applications to Stage II research methods conducted by my lab."
Major
Biology
Minor
N/A
Research Interests
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Intracranial Ependymomas
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Etiology, Presentation, Diagnosis, Treatment Cerebellar Hemorrhage
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Current Controversies and Treatment Thoracolumbar Spinal Fractures
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Classification and Treatment Regulation of Renin Angiotensin System (RAS)
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Reference to Ischemic Stroke Minimizing Immunosuppression in Hand and Organ Transplantation Reconstructive Transplantation VS Organ Transplantation
Academic Awards
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HHMI Research Award (2010-2011)
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University Scholars Award (2011-2012)
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Presidential Award for Academic Excellence (2010-2012)
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Dean's List for Academic Achievement (2010-2011)
Organizations
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Gainesville Equal Access Clinic
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Vanderbilt Medical/Mcknight Brain Institute (Joint-research study)
Volunteer
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Streetlight
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Shands Pediatrics Unit Sydney Lanier
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Physical Rehabilitation Interface- Heal the World
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Peer Mentorship Underprivileged Tutoring for Local Students in Gainesville Community
Hobbies and Interests
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Cooking
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Computer Programming
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Weight Training
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Rugby
Research Description
Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke
An increasing number of studies indicate that the angiotensin type 2 receptor (AT2R) in the CNS exerts beneficial actions in ischemic stroke. Furthermore, evidence indicates that AT2R expression is increased in the ischemic penumbra region following ischemic insult. Here we tested the effects of a specific AT2R agonist, Compound 21 (C21), on the cerebral deficits produced by endothelin-1 (ET-1) induced middle cerebral artery occlusion (MCAO). An increasing number of studies indicate that the angiotensin type 2 receptor (AT2R) in the CNS exerts beneficial actions in ischemic stroke. Furthermore, evidence indicates that AT2R expression is increased in the ischemic penumbra region following ischemic insult. Here we tested the effects of a specific AT2R agonist, Compound 21 (Cp21), on the cerebral deficits produced by endothelin-1 (ET-1) induced middle cerebral artery occlusion (MCAO). These data represent the idea that in order for C21 related cerebroprotection to occur, there must be a dimerization between the AT2R and the Mas receptors.