Mentor: Dr. Yi Zhang
College of Agricultural and Life Sciences
"I applied to the University Scholars program because it was a unique opportunity that caught my eye. I hope to experience the workings of the research process. My goals for the academic year are completing the project and the paper associated and getting the paper published."
Food Science and Human Nutrition
Hobbies and Interests
Change in leptin concentrations of CSF are different between two different species of rats
Leptin is an adipose derived hormone integral in regulating energy intake and energy expenditure. It is found in the plasma, the brain and the cerebrospinal fluid (CSF). According to Schwartz et al., leptin concentrations in CSF were strongly correlated to the plasma levels and body mass index (BMI). Thus, indicating that leptin enters the CSF in proportion to body adiposity. According to the Centers of Disease Control and Prevention (CDC), 35.7% of adults in the United States are obese. This does not include those who are overweight or children who are overweight or obese. When combating obesity, clinicians often turn to weight loss programs first. Weight loss programs have been reported to have different rates of success. The magnitude of change in CSF leptin concentrations may be an indication of how well a patient does while on a weight loss program. Sprague Dawley (SD) rats have been known to be obesity prone while the F344xBN (BN) rats retain leptin sensitivity despite consumption of high fat (HF) diet.