Scott Stratman

Mentor: Dr. Tong Zheng
College of Medicine
 
"Coming from a small, private high school, I never had a clear perspective about the scientific theory or what it meant to do "research." Originally, I pursued a research position at the McKnight Brain Institute because Neurosurgery had always piqued my interest. However, as time progressed and under the tutelage of my research mentor, I have learned to truly appreciate the goals of scientific research in its many forms. Conducting research is more than just simply using a pipette in front of a few beakers; it is one of the rawest forms of learning and epitomizes the pursuit of knowledge. Through the University Scholars program, I have been fortunate enough to continue a pursuit in my realm of research and constantly look forward to the fruits of my labor. "

Major

Biology and Psychology

Minor

Health Science

Research Interests

  • Neuroregeneration
  • Stem Cell Therapy
  • Nutraceuticals

Academic Awards

  • Phi Kappa Phi Love of Learning Scholarship
  • HHMI Undergraduate Research Scholarship
  • UF Presidential Service Award
  • President's Honor Roll 2011-2014

Organizations

  • American Medical Student Association
  • College of Liberal Arts and Sciences Ambassadors
  • Health Outreach and Quality Improvement Program

Volunteer

  • Equal Access Clinic Network
  • TOPSoccer
  • Haven Hospice

Hobbies and Interests

  • Tutoring/Education
  • Music (EDM)
  • Sensory Deprivation Tanks
  • Nature/Hiking/Trails

Research Description

Xenograft Model for Testing Nutrient Enhancers of Neurogenesis
A previous xenograft protocol was developed using Adult human neural stem/progenitor cells (AHNPs) and fetal human neural progenitor cells (HNPCs) in order to develop an accurate model for nutrient testing. Our previously established xenograft protocol will be used to further investigate whether human induced pluripotent stem (hIPS) cells and human mesenchymal stem cells (hMSCs) can be used as additional accurate and reliable models for future nutrient testing. Green fluorescence protein (GFP) labeled hIPS cells and hMSCs will be collected and transplanted into the cortex and lateral ventricles of immunodeficient mice. After various survival periods (ranging from 7-60 days), immunodeficient mice will be sacrificed and their brains harvested in order to collect representative tissue sections. These tissue sections will receive a battery of neuronal markers and human specific markers to examine the degree of differentiation and survival of the xenografted cells. Survival, migration, fate choice and differentiation of grafted cells will also be investigated. This will be accomplished through a stereological approach to quantify: 1) number of total cells present after grafting, 2) percentages of different cell populations, and 3) migration of target cells. Once this xenograft model is established, different nutrient supplements can be tested in these animals to determine potential beneficial outcomes in the growth, development, survival, and differentiation of hIPS cells and hMSCs.