Mentor: Dr. Todd Golde
College of Medicine
"When I applied to the Scholars program I hoped to understand how research is conducted and whether or not I am able to become a scientist based on my performance."
- Fusion of Engineering and Medicine
- Biomedical Engineering Society
Hobbies and Interests
- Solving Technical Problems
Effects of Classically and Alternatively Activated Innate Immune Cells on Neurodegeneration
My research is on investigating the effects of activated immune cells in models of neurodegenerative diseases such as Alzheimer's disease. The project involves implantation of microglial cells derived from primary mixed glial culture into the brain of mice. The cells will first be treated with different cytokines to "activate" the cells into either a anti-inflammatory (M2) or pro-inflammatory (M1) phenotype. After injection, mice will be bred and tissue will be collected at various time points. Tissue will be processed and analyzed by various immunoassays to determine levels of various proteins such as amyloid beta. This project will allow us to determine how purified microglia with a predefined phenotype can affect the brain protein levels in mouse models of neurodegenerative diseases.