Mentor: Dr. Xin Qi
College of Pharmacy
"I have developed an interest in the fields of physical sciences that are dedicated to providing health care for people both directly, such as physicians, and indirectly, such as researchers."
- Bill Baggs Cape Florida State Park
Hobbies and Interests
Metabolomic Approach to Profile Tobacco-induced Lung Damage
Metabolomics represents a powerful and attractive technology to assess tobacco smoke exposure and its impact on human health. A metabolomic approach is capable of analyzing thousands of different metabolites simultaneously and quantitatively within a given sample and profiling phenotypes based on clusters of metabolites. Therefore, metabolomic information will facilitate the development of a more accurate early diagnostic method for organ damage due to long-term tobacco usage. This proposal will focus on developing an innovative metabolomic approach for the identification of small molecule biomarkers leading to the early detection of tobacco-induced lung injury. Our method involves the comparative screening of blood, serum and tissue samples of Florida patients with lung cancers and normal controls obtained from the UF Clinical and Translational Science Institute (CTSI) Biorepository to provide valuable information for lung cancer treatment optimization. By integrating a metabolomic approach with the studies on the mechanism of functions of biomarkers in lung disease development, this breakthrough technology will significantly decrease the amount of time and effort required to screen very large number of patient samples with less off-target effects. Our studies will have a high impact on developing novel and specific methods for the early diagnosis and detection of lung damage.