Zhinous Hosseini

 
Mentor: Dr. Xin Qi
College of Pharmacy
"Getting involved in research in Medicinal Chemistry expands my knowledge of drug discovery procedures. It also gives me an outlet to apply all of the challenging techniques that I may not have learned in class, which allows me to obtain an in depth appreciation of concepts.research experience also opens up new sights to explore career pathways by identifying personal areas of interest and talent."

Major

Biochemistry

Minor

N/A

Research Interests

  • Potential biomarkers causing Mitochondrial disorder, Sarcopenia
  • Peptoid synthesis and its applications
  • Employing RNA extraction Methods in approach to possible drug discoveries to breast cancer

Academic Awards

  • Excellence in Performance Award in general biology
  • Graduated with Honors for AA degree
  • IASF Scholarship
  • University Scholars Program

Organizations

  • Phi Theta Kappa Honor Society
  • Pharmacy club
  • Chemistry club

Volunteer

  • CNA assistant at Brooks Rehabilitation Hospital
  • Translator at Catholic Charities Church Immigration Office
  • ESL Instructor in Turkey

Hobbies and Interests

  • Collecting Foreign Currency
  • Writing Diary
  • Traveling and exploring new places
  • Reading Journals and books

Research Description

Personalized Medicine in Effective Breast Cancer Treatment via Microarray Technology
Despite massive effort, breast cancer continues to devastate the lives of many people worldwide. The development of a more accurate early diagnostic method and a highly efficient drug with less toxicity and low cost is in urgent need. Our study focuses on developing innovative technologies in peptoid synthesis and applications for the isolation of synthetic ligands that recognize their target protein biomarkers in breast cancer patient serum and tissue with high affinity and selectivity. An efficient and facile peptoid library screening via microarray technology (SMART) is applied here for identifying novel ligands that act as capture agents and characterizing diagnostically useful antibodies through protein ID. Our initial studies obtained information of gene regulation associated with 128 breast cancer patient specimens and controls from UF Clinical and Translational Science Institute (CTSI) Biorepository. By integrating peptoid microarray screens with the studies on the mechanism of functions of protein biomarkers in breast cancer development, this breakthrough technology will significantly decrease the amount of time and effort required to screen very large libraries with less off-target effects. Our studies will have high impact on developing novel and specific methods for the early diagnosis and treatment of breast cancer.